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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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X-376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) with an IC50 of 0.61 nM. It is also a less potent inhibitor of MET (IC50=0.69 nM) and exhibits potent anti-tumor activity.
Effective in inhibiting the growth of various cancer cell lines, including H3122 lung cancer cells (IC50: 77 nM), H2228 lung cancer cells (IC50: 57 nM), and SUDHL-1 lymphoma cells (IC50: 32 nM).
Also inhibits SY5Y neuroblastoma cells, MKN-45 gastric carcinoma cells, HepG2 cells, and PC-9 lung cancer cell lines.
Demonstrates substantial bioavailability and moderate half-lives in vivo.
Significantly delays tumor growth in H3122 xenografts at a dose of 50 mg/kg bid, appearing well-tolerated without affecting mouse weight or causing compound-related toxicity.
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Inaxaplin (VX-147) is a small-molecule apolipoprotein L1 (APOL1) function inhibitor used in research on APOL1-mediated kidney disease. Supplied for research use only, the compound is characterized for in vitro and translational studies and is available as a high-purity solid and as a DMSO solution for biochemical and cell-based assays.
Potent APOL1 inhibition suitable for mechanism-of-action studies.
Intended for research use only and not for clinical use.
Available as a high-purity solid and as a 10 mM DMSO solution.
High reported purity supports reproducible experimental results.
Suitable for biochemical, cellular, and translational research on kidney disease.
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Chemical. CAS 3825-26-1. Formula C8HF15O2 . NH3. Molecular Weight 431.1. Perfluorooctanoate PFOA is the dissociated carboxylate anion of perfluorooctanoic acid and its salts. PFOA is a stable, soluble surfactant primarily used in the form of the ammonium salt APFO as a processing aid in the production of various fluoropolymers. It is a very active fluorosurfactant with high stability.
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