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Organic compounds in which a hydrogen atom or more has been replaced by a halogen atom in an alkane molecule (saturated hydrocarbon chain). Halogen atoms include bromine, chlorine, fluorine, and iodine. Compounds may be in closed ring configurations.
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Bis(2-bromoethyl) ether is an alkyl chain-based PROTAC linker that can be utilized in the synthesis of PROTACs. PROTACs themselves consist of two distinct ligands joined by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein. These molecules function by harnessing the intracellular ubiquitin-proteasome system to achieve the selective degradation of target proteins.
It is an alkyl chain-based linker.
It can be used in the synthesis of PROTACs.
The linked PROTACs exploit the intracellular ubiquitin-proteasome system.
The linked PROTACs selectively degrade target proteins.
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